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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop

Of interest, an enlarged dorsal muscle area was noted in gilthead seabream fed diets supplemented with 2%, 5%, or 8% creatine [42]

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Allow the vial to reach room temperature before opening to prevent condensation inside the container